The article was written by Bloomberg. It doesn't mention a direct quote by Downey, so I'm going to assume they are the Bloomberg writer's own words.

Not after being doused in makeup and qualudes, at least.

The preferred term by make-up artists is "spackled".

Qualudes? What year is it?

Quaaludes! The most fun word in the world to spell.

It is a fun word, isn't it? 'Whenever I become anxious I don't have qualia, I take some Quaaludes.'

Or rather, when they do, they at least have the decency to call it "art."