I actually like writing GTK way more then Qt. I like the fact it is C and easily integrates with any language I wish to use.
Though I use Qt, the Mac support on GTK is terrible at best. Windows support is even worse (or non-existent) which makes me question their "cross platform gui" title.
If I was to suggest a method, I would suggest using each platforms GUI language and make a backend in something cross platform.
And Mac with X11 emulator/vm/what ever XQuartz is. And Windows if you use the 2 year old version that has a ton of issues (UI bugs, glitches, old GTK bugs, etc).
Running on multiple Linux DE's/OS's is not cross platform as far as I am concerned, even though technically it is lol.
That's not what people mean when they say "cross platform".
"Cross platform" means supporting all of the widely-used platforms at a given point in time, and supporting them well. Today, that includes at least Windows, OS X, and Linux. Some would even extend that to include the BSDs, Solaris, AIX and HP-UX.
Like others have pointed out, GTK+'s support for OS X and Windows has been very, very lacking. It's nowhere near as seamless as that offered by Qt, Swing, or SWT.
Qt, WxWidgets, or even something else.
I'm so glad the Web and Modern Browsers reinvented "desktop applications".