I'd be quite curious to see this combined with [transcranial] photobiomodulation - a two-pronged approach to healthy mitochondria might pay healthy dividends.

For those hearing about PBM and feeling skeptical, I was as well, especially with all the claims of therapeutic "red light therapy" circling the internet. But do a quick search in pubmed and you will see that at this point there have been thousands of studies exploring the use of PBM (808-1064nm)

I quickly found these two which relate to sleep quality:

https://pbmfoundation.org/brain-photobiomodulation-improves-...

https://pubmed.ncbi.nlm.nih.gov/41125953/

If anyone is interested in PBM I gave an overview presentation a few months ago to a lab studying noninvasive neurostimulation, I would be happy to send it your way.

Maybe even a Tell HN post?

I would indeed be interested!

quite interested; email in bio.

Effects seen at .35g/kg and .2g/kg. Both pretty big doses. Which is not uncommon for creatine for a single day, but ongoing dose is typically lower.

I’ve taken creatine for exercise recovery and possible cognitive improvements when I was a vegetarian. Never perceived it to do anything.

Unless I did my math wrong:

I’m 150ish pounds. 72 kg. Meaning .35g per kg is 25g.

That’s 5x what I take! Just 5g once a day.

So far on creatine: quite significant physical effects (I lift often too). Cognitive: very unclear, have to isolate away a million other things.

I've noticed a difference in energy, small but present. Maybe 20% more reps before failure. Seems to match expectations from the literature.

Every post about creatine wants you to drink an absurd amount of it. I tried it for 3 days and ended up with a level of diarrhea that I’ve previously never encountered without being sick

I haven't experienced anything on the standard 5g/day. I've taken 20g/day saturating for a week straight before too and nothing there either, although by that point there is a bit more "taste" in the liquid. Same taste imo as a pure caffeine tablet, oddly.

If tired chess rating goes down, if well rested chess rating goes up. If high dose of creatine and tired chess rating goes up. Having big chess addiction good measurement device of cognitive function. I endorse creatine for tired people that need brain working.